Thorne Methyl-Guard Plus Thorne Methyl-Guard Plus is an advanced methylation support formula designed to promote cardiovascular, cognitive, bone, and neurological health.* This comprehensive supplement provides active, tissue-ready B vitamins and key methyl donors to support the body’s essential methylation pathways.* Formulated by Thorne, Methyl-Guard Plus delivers 5-MTHF (active folate) along with the active forms of vitamin B2 (riboflavin-5′-phosphate), vitamin B6 (pyridoxal-5′-phosphate), and vitamin B12 (methylcobalamin), plus betaine (trimethylglycine).* These nutrients work synergistically to support healthy methylation and help maintain normal homocysteine levels—an important marker for cardiovascular health.* Methylation plays a critical role in numerous biochemical processes, including neurotransmitter synthesis, detoxification, redox balance, and cellular repair.* By supporting healthy homocysteine metabolism, Methyl-Guard Plus also helps maintain bone health, cognitive and neurological function, eye health, muscle health, and female reproductive health.* Key Benefits: Supports healthy methylation processes* Helps maintain normal homocysteine levels* Promotes cardiovascular and blood vessel health* Supports cognitive, neurological, and mood health* Helps maintain bone and muscle health* Provides active, tissue-ready B vitamins for optimal utilization*