Interleukin-23 (IL-23) is a pro-inflammatory heterodimeric protein consisting of two subunits: a unique p19 subunit and a p40 subunit shared with IL-12.IL-23 is secreted by activated dendritic cells and macrophages and signals through the receptor for IL-23R in complex with IL-12Rβ1. IL-23 has been shown to enhance the proliferation of memory T cells.IL-23 also stimulates the production of IFN-γ in NK cells, induces IL-17 production, and drives Th17-mediated responses. This Recombinant Human IL-23 is supplied in liquid form and is highly active, highly pure, low endotoxin, and label free. Specification Synonyms Interleukin-23;IL-23 p19/IL-12 p40; IL23; IL-23; IL-23A; IL-23-A; IL-23p19; IL-23p19/IL-12p40; IL23P19P1;NKSF2;IL-12B&IL-23A Source HEK293 Sequence p40 (Met1-Ser335) & p19 (Val22-Ala196) Accession P43432 (p40) & Q9EQ14 (p19) Molecular Weight Predicted Moleucular weight: 57.9 kDa Endotoxin < 0.01 EU/μg by the LAL method. Purity > 95%，determined by SDS-PAGE Biological Activity Measured by its ability to induce IL-17 secretion by mouse splenocytes. The EC50 for this effect is 0.005-0.25 ng/mL. Formulation Dissolved in sterile PBS buffer. Tag Not Physical Appearance Fluids concentration 0.2 mg/mL Storage -85~-65℃ storage, valid for 1 year after receipt. Avoid repeated freezing and thawing, centrifuge before opening the vial. It is recommended to aliquot for one experimental use, after aliquoting, freeze at -80℃. Cautions 1. Please operate with lab coats and disposable gloves,for your safety. 2. This product is for research use only.
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