Interleukin-15 (IL-15) is an immunomodulatory cytokine that stimulates the proliferation of T-lymphocytes.IL-15 exerts its biological activity primarily on T-cells. It is also essential for the development, survival and activation of NK cells.Increased expression of IL-15 has been associated with rheumatoid arthritis, inflammatory bowel disease, and diseases associated with the retroviruses HIV and HTLV-I.The expression of IL-15 has been shown to be associated with the development of T lymphocytes. Human IL-15 is biologically active against mouse CTLL cells as measured by dose-dependent stimulation of cell proliferation. This recombinant human IL-15 is supplied as Lyophilized powder with high activity, high purity, low endotoxin, and NO labeling. Product Properties Synonyms IL15, Interleukin-15, IL-15, MGC9721 Species Human Source CHO Cells Sequence Asn49-Ser162 Accession P40933 Tag NO Molecular Weight Predicted molecularmass：12.7 kDa Endotoxin ≤10 EU/mg by the LAL method Purity ≥95%, by SDS-PAGE (under reducing (R) & Non-reducing conditions, visualized by Coomassie staining) Activity Measured in a cell proliferation assay using CTLL-2 mouse cytotoxic Tcells. The ED50 for this effect is ≤0.5ng/ml. Formulation Lyophilized from a 0.22 μm-filtered solution containing PBS, 5% mannitoland 0.01% Tween 80, pH 7.4 Appearance Lyophilized powder Shipping and Storage -25 ~ -15 ° C storage, from the date of receipt of goods, the expiration date of 1 year. After re-solution, store at 2 ~8 °C, 7-10 days expiration date. After re-dissolution, -85 ~ -65 ° C storage, 6 months expiration date. Compounding method Use NO bacterial deionized water to reconstitute lyophilized proteins. It is recommended that proteins be divided for first use to avoid repeated freeze-thawing. Figure Figure 1.Measured in a cell proliferation assay using CTLL-2 mouse cytotoxic T cells. The ED50 for this effect is ≤ 0.5ng/ml. Figure 2.Human IL-15 Protein on SDS-PAGE under reducing (R) condition. The purity is greater than 95%. Cautions 1. For your safety and health, please wear lab coat and disposable gloves. 2. This product is for scientific research purposes only.
