Hemoglobin Protease Substrate Catalog number: B2013002 Lot number: Batch Dependent Expiration Date: Batch dependent Amount: 10 g Molecular Weight or Concentration: N/A Supplied as: Lyophilized Powder Applications: molecular tool for various biochemical applications Storage: -20°C Keywords: Hemoglobin from bovine blood, Bovine hemoglobin, Hb, Methemoglobin Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um. References Pandey KC, Wang SX, Sijwali PS, Lau AL, McKerrow JH, Rosenthal PJ. The Plasmodium falciparum cysteine protease falcipain-2 captures its substrate, hemoglobin, via a unique motif Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9138-43. Singh V, Hada RS, Uddin A, Aneja B, Abid M, Pandey KC, Singh S. Inhibition of Hemoglobin Degrading Protease Falcipain-2 as a Mechanism for Anti-Malarial Activity of Triazole-Amino Acid Hybrids Curr Top Med Chem. 2020;20(5):377-389. De Lumen BO, Tappel AL. Fluorescein-hemoglobin as a substrate for cathepsin D and other proteases Anal Biochem. 1970 Jul;36(1):22-9. Sharma A, Eapen A, Subbarao SK. Purification and characterization of a hemoglobin degrading aspartic protease from the malarial parasite Plasmodium vivax J Biochem. 2005 Jul;138(1):71-8. Arcoleo JP, Greer J. Hemoglobin binding site and its relationship to the serine protease-like active site of haptoglobin J Biol Chem. 1982 Sep 10;257(17):10063-8. Pasupureddy R, Verma S, Pant A, Sharma R, Seshadri S, Pande V, Saxena AK, Dixit R, Pandey KC. Crucial residues in falcipains that mediate hemoglobin hydrolysis Exp Parasitol. 2019 Feb;197:43-50. Junaid MA, Brooks SS, Pullarkat RK. Specific substrate for CLN2 protease/tripeptidyl-peptidase I assay Eur J Paediatr Neurol. 2001;5 Suppl A:63-8. Williams HR, Lin TY. Methyl- 14 C-glycinated hemoglobin as a substrate for proteases Biochim Biophys Acta. 1971 Dec 15;250(3):603-7. Istvan ES, Goldberg DE. Distal substrate interactions enhance plasmepsin activity J Biol Chem. 2005 Feb 25;280(8):6890-6.
