Human IgG for Interference Testing Catalog # B2013169 Lot # Batch Dependent Expiration Batch Dependent Amount 5 mg Concentration Not applicable Supplied as Powder Applications Biochemical interference testing and assay validation Storage –20°C Keywords Human IgG, Immunoglobulin G (IgG) Grade Biotechnology grade; ultrapure water, 0.22 µm filtered This high-purity Human IgG reagent is supplied as a lyophilized powder and optimized for interference testing in immunoassays, biochemical workflows, and analytical platforms. Immunoglobulin G (IgG) is the most abundant antibody isotype in human serum and plays a central role in immune response and assay interference. Its presence can affect signal detection, binding specificity, and assay reproducibility, making it a critical control material for validation studies. Packaged in 5 mg aliquots and stored at –20°C, this biotechnology-grade reagent is suitable for reconstitution in Type I ultrapure water (resistivity >18 MΩ·cm). It is ideal for developers evaluating IgG cross-reactivity, Fc receptor binding, and subclass-specific interference. The material is filtered through 0.22 µm membranes and processed under stringent quality controls to ensure consistency across batches. Compatible with ELISA, CLIA, lateral flow, and multiplex platforms. Key benefits: Human IgG powder for interference testing and assay validation Supports Fc receptor binding studies and subclass-specific analysis Filtered and aliquoted for reproducibility and long-term storage Compatible with immunoassay and biochemical platforms Biotechnology grade; reconstitutable in ultrapure water Indication for Use:This product is for Research Use Only (RUO). This product is not for administration to humans or animals. This product is not for human or veterinary diagnostic or therapeutic use. References:1: Bruhns P. Properties of mouse and human IgG receptors and their contribution to disease models Blood. 2012 Jun 14;119(24):5640-9.2: Dekkers G, Bentlage AEH, Stegmann TC, Howie HL, Lissenberg-Thunnissen S, Zimring J, Rispens T, Vidarsson G. Affinity of human IgG subclasses to mouse Fc gamma receptors MAbs. 2017 Jul;9(5):767-773.3: Heijnen IA, van de Winkel JG. Human IgG Fc receptors Int Rev Immunol. 1997;16(1-2):29-55.4: Hamilton RG. Human IgG subclass measurements in the clinical laboratory Clin Chem. 1987 Oct;33(10):1707-25.5: Chenoweth AM, Trist HM, Tan PS, Wines BD, Hogarth PM. The high-affinity receptor for IgG, FcγRI, of humans and non-human primates Immunol Rev. 2015 Nov;268(1):175-91.6: Tamm A, Schmidt RE. IgG binding sites on human Fc gamma receptors Int Rev Immunol. 1997;16(1-2):57-85.7: Semmes EC, Li SH, Hurst JH, Yang Z, Niedzwiecki D, Fouda GG, Kurtzberg J, Walsh KM, Permar SR. Congenital Human Cytomegalovirus Infection Is Associated With Decreased Transplacental IgG Transfer Efficiency Due to Maternal Hypergammaglobulinemia Clin Infect Dis. 2022 Apr 9;74(7):1131-1140.8: Shete AM, Jain R, Mohandas S, Pardeshi P, Yadav PD, Gupta N, Mourya D. Development of Nipah virus-specific IgM & IgG ELISA for screening human serum samples Indian J Med Res. 2022 Sep;156(3):429-434.9: Wang B, Goodman J, Roskos LK. Mechanistic modeling of a human IgG(4) monoclonal antibody (tralokinumab) Fab-arm exchange with endogenous IgG(4) in healthy volunteers CPT Pharmacometrics Syst Pharmacol. 2022 Apr;11(4):438-446.10: Wang Y, Krémer V, Iannascoli B, Goff OR, Mancardi DA, Ramke L, de Chaisemartin L, Bruhns P, Jönsson F. Specificity of mouse and human Fcgamma receptors and their polymorphic variants for IgG subclasses of different species Eur J Immunol. 2022 May;52(5):753-759.
