Description PAN-Biotech Panexin CD is a chemically defined, xeno-free serum replacement for the cultivation of adherent and non-adherent cells under serum-free culture conditions or to significantly reduce the amount of serum in cell culture. It supports the growth of many cell types in an optimum manner without any extra handling compared to serum. A GMP Grade version is now available: Panexin CD, Serum Replacement with Chemically-Defined Components, GMP Grade. Composition Panexin CD is free of any animal or human-derived components. It contains recombinant proteins, lipids, salts, amino acids, trace elements, hormones and a 3-dimensional substrate release system in an optimized formulation. It contains no growth factors, undefined hydrolysates or peptones. Advantages Panexin CD is designed to replace or to reduce serum in the cell culture in a very simple manner. Compared to other serum replacements, it contains only chemically defined components. Due to its very defined character, lot testing is not necessary anymore. It also allows high reproducibility and simplified downstream processing. Panexin CD contains no growth factors and enables defined proliferation and differentiation of stem cells. Characterization studies of growth factors will obtain more reproducible and clearer results. Panexin CD is also useful to develop sensitive cell-based in vitro tests and coculture procedures. For cell lines which require specific growth factors these should be added in a concentration as previously used. Suitability Panexin CD is suitable for the cultivation of a variety of adherent and suspension cells under serum-free culture conditions or to reduce the necessary FBS amount in cell culture (see Fig.1). For instructions on cell adaptation from FBS, please refer to the Product Datasheet (PDS) and Application Note. Specifications Cat. No. P04-93050, P04-93100, P04-930500 Quality: Research Use Only (RUO) Cell Type: Various Culture Type: Adherent culture or suspension culture Liquid / Powder: liquid Product Category: Serum Replacements Size: 50 ml, 100 ml, or 500 ml bottles Sterile: Yes Storage Temperature: -20°C, in the dark Manufacturer: PAN-Biotech GmbH Country of Origin: Germany Usage This product is intended for Laboratory Research Use Only. Not for use in diagnostic or therapeutic procedures. This product may not be used as a pharmaceutical or veterinary drug, agricultural product, or food additive. Other Names FBS replacement, FBS substitute, serum substitute Resources Product Datasheet (PDS) Application Note Material Safety Data Sheet (MSDS) Panexin Product References Product References Skowronek, Dariush et al. “High-throughput differentiation of human blood vessel organoids reveals overlapping and distinct functions of the cerebral cavernous malformation proteins.” Angiogenesis vol. 28,3 32. 6 Jun. 2025, doi:10.1007/s10456-025-09985-5 Babutzka, Sabrina et al. “A novel platform for engineered AAV-based vaccines.” Molecular therapy. Methods & clinical development vol. 33,1 101418. 22 Jan. 2025, doi:10.1016/j.omtm.2025.101418 Kohs, Jessica et al. “Studies on the Virucidal Effects of UV-C of 233 nm and 275 nm Wavelengths.” Viruses vol. 16,12 1904. 11 Dec. 2024, doi:10.3390/v16121904 Perez-Diaz, Noelia et al. “Longitudinal characterization of TK6 cells sequentially adapted to animal product-free, chemically defined culture medium: considerations for genotoxicity studies.” Frontiers in toxicology vol. 5 1177586. 4 Jul. 2023, doi:10.3389/ftox.2023.1177586 Gehrke, Miranda et al. “Immunogenicity of Novel AAV Capsids for Retinal Gene Therapy.” Cells vol. 11,12 1881. 9 Jun. 2022, doi:10.3390/cells11121881 Related Products Panexin CD, Serum Replacement with Chemically-Defined Components, GMP Grade Panexin Serum Replacements Serum-Free Media Ilex Life Sciences LLC is an authorized distributor of PAN-Biotech GmbH.
