Interleukin-34 (IL-34) is a cytokine with a molecular weight of 23.98 kDa, consisting of 216 amino acid residues. IL-34 is a ligand for the colony-stimulating factor 1 receptor (CSF-1R) and is primarily secreted by the adrenal glands, frontal lobe, and cortex. It plays a crucial role in the proliferation, survival, differentiation, and migration of myeloid cells. These functions are mediated by IL-34 activating the ERK1/2, JAK, and PI3K/AKT signaling pathways. Specifications Cat.No. 90297ES08 / 90297ES20 / 90297ES60 / 90297ES76 Size 5 μg / 20 μg / 100 μg / 500 μg Components Name 90297ES08 90297ES20 90297ES60 90297ES76 HiActi™ Recombinant Mouse IL-34 Protein ,His Tag 5 μg 20 μg 100 μg 500 μg Performance parameters Synonyms interleukin 34, C16orf77, IL34 Species Mouse Expression Sequence MNEPLEMWPLTQNEECTVTGFLRDKLQYRSRLQYMKHYFPINYKISVPYEGVFRIANVTRLQRAQVSERELRYLWVLVSLSATESVQDVLLEGHPSWKYLQEVETLLLNVQQGLTDVEVSPKVESVLSLLNAPGPNLKLVRPKALLDNCFRVMELLYCSCCKQSSVLNWQDCEVPSPQSCSPEPSLQYAATQLYPPPPWSPSSPPHSTGSVRPVRAQGEGLLP with polyhistidine tag at the C-terminus. Accession Q6ZMJ4 Tag C-His Expression System E.coli Molecular Weight The protein has a calculated MW of 26.17 kDa. The protein migrates as 30 kDa under reducing condition Purity >98% as determined by SDS-PAGE. Endotoxin