HiActi™ Recombinant Mouse IL-38 Protein, His Tag _ 90299ES

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Interleukin-38 (IL-38) is a cytokine with a molecular weight of 16.87 kDa, consisting of 152 amino acid residues, and belongs to the interleukin-1 (IL-1) family. IL-38 is primarily secreted by basal epithelial cells of the skin, as well as by B cells in the tonsils, spleen, and thymus. Upon binding to receptors such as IL1RAPL1 and IL-36R, IL-38 plays a crucial role in inflammation and host defense by mediating the NF-κB, AP-1, and JNK signaling pathways. Furthermore, IL-38 is involved in downregulating cell proliferation and migration, while upregulating the expression of IL-6 and IL-10. Specifications Cat.No. 90299ES08 / 90299ES020 / 90299ES60 / 90299ES76 Size 5 μg / 20 μg / 100 μg / 100 μg Components Name 90299ES08 90299ES20 90299ES60 90299ES76 HiActi™ Recombinant Mouse IL-38 Protein, His Tag 5 μg 20 μg 100 μg 500 μg Performance parameters Synonyms interleukin 38, interleukin 1 family member 10, IL1F10, FIL1-theta, FKSG75, IL-1HY2, IL1-theta, IL1HY2, IL38 Species Mouse Expression Sequence MCSLPMARYYIIKYADQKALYTRDGQLLVGDPVADNCCAEKICTLPNRGLDRTKVPIFLGIQGGSRCLACVETEEGPSLQLEDVNIEELYKGGEEATRFTFFQSSSGSAFRLEAAAWPGWFLCGPAEPQQPVQLTKESEPSARTKFYFEQSW with polyhistidine tag at the C-terminus. Accession Q8WWZ1 Tag C-His Expression System E.coli Molecular Weight The protein has a calculated MW of 17.78 kDa. The protein migrates as 21 kDa under reducing condition Purity >98% as determined by SDS-PAGE. Endotoxin Show more