Fluorogenic Furin Substrate Catalog number: B2012668 Lot number: Batch Dependent Expiration Date: Batch dependent Amount: 5 mg Molecular Weight or Concentration: 827.9 g/mol Supplied as: Lyophilized Powder Applications: molecular tool for various biochemical applications Storage: -20°C Keywords: Furin Substrate, Fluorogenic Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um. References Zhu J, Declercq J, Creemers JW, Chen C, Cui Y, Van de Ven WJ, Vermorken AJ. Limitations of inhibitory activities of polyphenols on furin-mediated substrate processing Curr Med Chem. 2012;19(21):3641-50. Angliker H, Neumann U, Molloy SS, Thomas G. Internally quenched fluorogenic substrate for furin Anal Biochem. 1995 Jan 1;224(1):409-12. Jean F, Basak A, DiMaio J, Seidah NG, Lazure C. An internally quenched fluorogenic substrate of prohormone convertase 1 and furin leads to a potent prohormone convertase inhibitor Biochem J. 1995 May 1;307 ( Pt 3)(Pt 3):689-95. Lam van TV, Ivanova T, Lindberg I, Böttcher-Friebertshäuser E, Steinmetzer T, Hardes K. Design, synthesis, and characterization of novel fluorogenic substrates of the proprotein convertases furin, PC1/3, PC2, PC5/6, and PC7 Anal Biochem. 2022 Oct 15;655:114836. Zaragoza-Huesca D, Martínez-Cortés C, Banegas-Luna AJ, Pérez-Garrido A, Vegara-Meseguer JM, Peñas-Martínez J, Rodenas MC, Espín S, Pérez-Sánchez H, Martínez-Martínez I. Identification of Kukoamine A, Zeaxanthin, and Clexane as New Furin Inhibitors Int J Mol Sci. 2022 Mar 3;23(5):2796. Tanikawa T, Hayashi T, Suzuki R, Kitamura M, Inoue Y. Inhibitory effect of honokiol on furin-like activity and SARS-CoV-2 infection J Tradit Complement Med. 2022 Jan;12(1):69-72. Fei H, Li Y, Wang LX, Luo MJ, Ling MH, Chi CW. Nonhistone protein purified from porcine kidney acts as a suicide substrate inhibitor on furin-like enzyme Acta Pharmacol Sin. 2000 Mar;21(3):265-70. Lazure C, Gauthier D, Jean F, Boudreault A, Seidah NG, Bennett HP, Hendy GN. In vitro cleavage of internally quenched fluorogenic human proparathyroid hormone and proparathyroid-related peptide substrates by furin. Generation of a potent inhibitor J Biol Chem. 1998 Apr 10;273(15):8572-80. Rozan L, Krysan DJ, Rockwell NC, Fuller RS. Plasticity of extended subsites facilitates divergent substrate recognition by Kex2 and furin J Biol Chem. 2004 Aug 20;279(34):35656-63.
